Victor Vale and Eli Cardale are brilliant calculating risk-takers and the smartest pre-med students at their prestigious university; they also happen to be best friends. For a class project, Eli decides to research the so-called E.O.'s--extraordinary people who seem to demonstrate abnormal abilities not unlike superpowers. What's more, during his research, Eli realizes that he might be able to synthesize an E.O., and he wants to try it on himself. What happens next leave both him and Victor changed forever.